MitoProteome Database

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MT000106

Gene Information

Entrez Gene ID841
Gene Namecaspase 8, apoptosis-related cysteine peptidase
Gene SymbolCASP8
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0031265 IDA:UniProtKBCCD95 death-inducing signaling complex
GO:0044297 IEA:EnsemblCcell body
GO:0005737 IDA:HPACcytoplasm
GO:0005856 TAS:ProtIncCcytoskeleton
GO:0005829 IDA:UniProtKBCcytosol
GO:0031264 IDA:UniProtKBCdeath-inducing signaling complex
GO:0045121 IEA:EnsemblCmembrane raft
GO:0005815 IDA:HPACmicrotubule organizing center
GO:0005741 TAS:ReactomeCmitochondrial outer membrane
GO:0005739 IDA:HPACmitochondrion
GO:0043005 IEA:EnsemblCneuron projection
GO:0030690 IEA:EnsemblCNoc1p-Noc2p complex
GO:0005634 IDA:HPACnucleus
GO:0097342 IDA:UniProtKBCripoptosome
GO:0004197 IDA:UniProtKBFcysteine-type endopeptidase activity
GO:0097153 IMP:UniProtKBFcysteine-type endopeptidase activity involved in apoptotic process
GO:0097199 IMP:UniProtKBFcysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0008234 TAS:ProtIncFcysteine-type peptidase activity
GO:0035877 IPI:UniProtKBFdeath effector domain binding
GO:0008233 IMP:UniProtKBFpeptidase activity
GO:0097110 IPI:ParkinsonsUK-UCLFscaffold protein binding
GO:0031625 IPI:UniProtKBFubiquitin protein ligase binding
GO:0097202 IDA:BHF-UCLPactivation of cysteine-type endopeptidase activity
GO:0006919 TAS:ReactomePactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0001525 IEA:EnsemblPangiogenesis
GO:0006915 IMP:UniProtKBPapoptotic process
GO:0097190 IMP:BHF-UCLPapoptotic signaling pathway
GO:0042113 TAS:UniProtKBPB cell activation
GO:0006921 TAS:ReactomePcellular component disassembly involved in execution phase of apoptosis
GO:0071260 IEP:UniProtKBPcellular response to mechanical stimulus
GO:0071407 IEA:EnsemblPcellular response to organic cyclic compound
GO:0097194 IMP:UniProtKBPexecution phase of apoptosis
GO:0097191 IDA:UniProtKBPextrinsic apoptotic signaling pathway
GO:0008625 IBA:RefGenomePextrinsic apoptotic signaling pathway via death domain receptors
GO:0007507 IEA:EnsemblPheart development
GO:0097284 IEA:EnsemblPhepatocyte apoptotic process
GO:0045087 TAS:ReactomePinnate immune response
GO:0097193 TAS:ReactomePintrinsic apoptotic signaling pathway
GO:0030225 TAS:UniProtKBPmacrophage differentiation
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0030101 TAS:UniProtKBPnatural killer cell activation
GO:0043124 IMP:UniProtKBPnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0060546 IEA:EnsemblPnegative regulation of necroptotic process
GO:0001841 IEA:EnsemblPneural tube formation
GO:0035872 TAS:ReactomePnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0070423 TAS:ReactomePnucleotide-binding oligomerization domain containing signaling pathway
GO:2001238 IEA:EnsemblPpositive regulation of extrinsic apoptotic signaling pathway
GO:0043123 IMP:UniProtKBPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045651 IMP:UniProtKBPpositive regulation of macrophage differentiation
GO:1900740 TAS:ReactomePpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0045862 IDA:BHF-UCLPpositive regulation of proteolysis
GO:0051291 IEA:EnsemblPprotein heterooligomerization
GO:0006508 IDA:UniProtKBPproteolysis
GO:0051603 IMP:BHF-UCLPproteolysis involved in cellular protein catabolic process
GO:2001239 TAS:ReactomePregulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0070243 IEA:EnsemblPregulation of thymocyte apoptotic process
GO:0046677 IEA:EnsemblPresponse to antibiotic
GO:0032025 IEA:EnsemblPresponse to cobalt ion
GO:0009409 IEA:EnsemblPresponse to cold
GO:0032355 IEA:EnsemblPresponse to estradiol
GO:0045471 IEA:EnsemblPresponse to ethanol
GO:0032496 IEA:EnsemblPresponse to lipopolysaccharide
GO:0034612 IMP:BHF-UCLPresponse to tumor necrosis factor
GO:0060715 TAS:UniProtKBPsyncytiotrophoblast cell differentiation involved in labyrinthine layer development
GO:0042110 TAS:UniProtKBPT cell activation
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0036462 IDA:ParkinsonsUK-UCLPTRAIL-activated apoptotic signaling pathway
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
GO:0016032 IEA:UniProtKB-KWPviral process
KEGG Pathway Links
KEGG Pathway IDDescription
hsa05010Alzheimer's disease
ko05010Alzheimer's disease
hsa04210Apoptosis
ko04210Apoptosis
hsa05142Chagas disease (American trypanosomiasis)
ko05142Chagas disease (American trypanosomiasis)
hsa05161Hepatitis B
hsa05168Herpes simplex infection
ko05168Herpes simplex infection
hsa05016Huntington's disease
ko05016Huntington's disease
hsa05134Legionellosis
ko05134Legionellosis
hsa04621NOD-like receptor signaling pathway
ko04621NOD-like receptor signaling pathway
hsa04932Non-alcoholic fatty liver disease (NAFLD)
ko04932Non-alcoholic fatty liver disease (NAFLD)
hsa04115p53 signaling pathway
ko04115p53 signaling pathway
hsa05200Pathways in cancer
hsa04622RIG-I-like receptor signaling pathway
ko04622RIG-I-like receptor signaling pathway
hsa04668TNF signaling pathway
ko04668TNF signaling pathway
hsa04620Toll-like receptor signaling pathway
ko04620Toll-like receptor signaling pathway
hsa05145Toxoplasmosis
ko05145Toxoplasmosis
hsa05152Tuberculosis
ko05152Tuberculosis
hsa05203Viral carcinogenesis
ko05203Viral carcinogenesis
hsa05416Viral myocarditis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_701Activation, myristolyation of BID and translocation to mitochondria
REACT_578Apoptosis
REACT_107Apoptotic cleavage of cellular proteins
REACT_995Apoptotic execution phase
REACT_1503Caspase-8 activation by cleavage
REACT_13541Caspase-mediated cleavage of cytoskeletal proteins
REACT_1619Death Receptor Signalling
REACT_832Dimerization of procaspase-8
REACT_1059Extrinsic Pathway for Apoptosis
REACT_900FasL/ CD95L signaling
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_964Intrinsic Pathway for Apoptosis
REACT_6809MyD88-independent cascade
REACT_25039NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
REACT_75776NOD1/2 Signaling Pathway
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_164011Regulation by c-FLIP
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_402TRAIL signaling
REACT_150361TRIF-mediated programmed cell death
REACT_25281TRIF-mediated TLR3/TLR4 signaling