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MT000109

UniProt Annotations

Entry Information

Gene Name	catalase
Protein Entry	CATA_HUMAN
UniProt ID	P04040
Species	Human

Comments

Comment type	Description
Catalytic Activity	2 H(2)O(2) = O(2) + 2 H(2)O. {ECO:0000255\|PROSITE-ProRule:PRU10013, ECO:0000269\|PubMed:7882369}.
Cofactor	Name=heme; Xref=ChEBI:CHEBI:30413;
Cofactor	Name=NADP(+); Xref=ChEBI:CHEBI:58349;
Disease	Acatalasemia (ACATLAS) [MIM:614097]: A metabolic disorder characterized by a total or near total loss of catalase activity in red cells. It is often associated with ulcerating oral lesions. {ECO:0000269\|PubMed:2308162}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Function	Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. {ECO:0000269\|PubMed:7882369}.
Ptm	The N-terminus is blocked.
Similarity	Belongs to the catalase family. {ECO:0000305}.
Subcellular Location	Peroxisome.
Subunit	Homotetramer.
Web Resource	Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cat/";
Web Resource	Name=Wikipedia; Note=Catalase entry; URL="http://en.wikipedia.org/wiki/Catalase";