MitoProteome Database

MT000112

Record overview

MITO ID	MT000112
Gene ID	885
Species	Homo sapiens (Human)
Gene Name	cholecystokinin
Gene Symbol	CCK
Alternate names	cholecystokinin; prepro-cholecystokinin; cholecystokinin triacontatriapeptide;
Chromosome	3
Map Location	3p22.1
Summary	Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of the gallbladder. In the brain, its physiologic role is unclear. The cholecystokinin pro-hormone is processed by endo- and exo-proteolytic cleavages. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
Orthologs	View orthologs and multiple alignments for CCK

Proteins

cholecystokinin preproprotein

Refseq ID:	NP_001167609
Protein GI:	292494892
UniProt ID:	P06307
mRNA ID:	NM_001174138
Length:	115
RefSeq Status:

`MNSGVCLCVLMAVLAAGALTQPVPPADPAGSGLQRAEEAPRRQLRVSQRTDGESRAHLGALLARYIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGW MDFGRRSAEEYEYPS`

N
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1937
peptide sequence: 
MNSGVCLCVLMAVLAAGALT

mat_peptide: 46..103
product: cholecystokinin-58
calculated_mol_wt: 6646
peptide sequence: 
VSQRTDGESRAHLGALLARYIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDF

mat_peptide: 65..103
product: cholecystokinin-39
calculated_mol_wt: 4626
peptide sequence: 
YIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDF

mat_peptide: 71..103
product: cholecystokinin-33
calculated_mol_wt: 3866
peptide sequence: 
KAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDF

mat_peptide: 92..103
product: cholecystokinin-12
calculated_mol_wt: 1536
peptide sequence: 
ISDRDYMGWMDF

mat_peptide: 96..103
product: cholecystokinin-8
calculated_mol_wt: 1064
peptide sequence: 
DYMGWMDF

sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1937
peptide sequence: 
MNSGVCLCVLMAVLAAGALT

mat_peptide: 46..103
product: cholecystokinin-58
calculated_mol_wt: 6646
peptide sequence: 
VSQRTDGESRAHLGALLARYIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDF

mat_peptide: 65..103
product: cholecystokinin-39
calculated_mol_wt: 4626
peptide sequence: 
YIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDF

mat_peptide: 71..103
product: cholecystokinin-33
calculated_mol_wt: 3866
peptide sequence: 
KAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDF

mat_peptide: 92..103
product: cholecystokinin-12
calculated_mol_wt: 1536
peptide sequence: 
ISDRDYMGWMDF

mat_peptide: 96..103
product: cholecystokinin-8
calculated_mol_wt: 1064
peptide sequence: 
DYMGWMDF

cholecystokinin preproprotein

Refseq ID:	NP_000720
Protein GI:	4502605
UniProt ID:	P06307
mRNA ID:	NM_000729
Length:	115
RefSeq Status:

Protein sequence is identical to GI:292494892 (mRNA isoform)

N
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1937
peptide sequence: 
MNSGVCLCVLMAVLAAGALT

mat_peptide: 46..103
product: cholecystokinin-58
calculated_mol_wt: 6646
peptide sequence: 
VSQRTDGESRAHLGALLARYIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDF

mat_peptide: 65..103
product: cholecystokinin-39
calculated_mol_wt: 4626
peptide sequence: 
YIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDF

mat_peptide: 71..103
product: cholecystokinin-33
calculated_mol_wt: 3866
peptide sequence: 
KAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDF

mat_peptide: 92..103
product: cholecystokinin-12
calculated_mol_wt: 1536
peptide sequence: 
ISDRDYMGWMDF

mat_peptide: 96..103
product: cholecystokinin-8
calculated_mol_wt: 1064
peptide sequence: 
DYMGWMDF