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MT000119

UniProt Annotations

Entry Information

Gene Name	creatine kinase, brain
Protein Entry	KCRB_HUMAN
UniProt ID	P12277
Species	Human

Comments

Comment type	Description
Catalytic Activity	ATP + creatine = ADP + phosphocreatine. {ECO:0000255\|PROSITE-ProRule:PRU10029}.
Function	Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Interaction	Q03463:- (xeno); NbExp=3; IntAct=EBI-357706, EBI-9081620; Q96DX5:ASB9; NbExp=3; IntAct=EBI-357706, EBI-745641;
Similarity	Belongs to the ATP:guanido phosphotransferase family. {ECO:0000255\|PROSITE-ProRule:PRU00842, ECO:0000255\|PROSITE- ProRule:PRU00843}.
Similarity	Contains 1 phosphagen kinase C-terminal domain. {ECO:0000255\|PROSITE-ProRule:PRU00843}.
Similarity	Contains 1 phosphagen kinase N-terminal domain. {ECO:0000255\|PROSITE-ProRule:PRU00842}.
Subcellular Location	Cytoplasm.
Subunit	Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain. {ECO:0000269\|PubMed:18977227}.
Web Resource	Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ckb/";
Web Resource	Name=Wikipedia; Note=CKB entry; URL="http://en.wikipedia.org/wiki/CKB_(gene)";
Web Resource	Name=Wikipedia; Note=Creatine kinase entry; URL="http://en.wikipedia.org/wiki/Creatine_kinase";