MitoProteome Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins

MT000126

UniProt Annotations

Entry Information

Gene Name	clathrin, heavy chain (Hc)
Protein Entry
UniProt ID
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q00610-1; Sequence=Displayed; Name=2; IsoId=Q00610-2; Sequence=VSP_011570, VSP_011571; Note=No experimental confirmation available.;
Domain	The N-terminal seven-bladed beta-propeller is formed by WD40-like repeats, and projects inward from the polyhedral outer clathrin coat. It consitutes a major protein-protein interaction node.
Function	Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
Interaction	P10242:MYB; NbExp=4; IntAct=EBI-354967, EBI-298355; Q01968:OCRL; NbExp=4; IntAct=EBI-354967, EBI-6148898; O75674:TOM1L1; NbExp=4; IntAct=EBI-354967, EBI-712991;
Sequence Caution	Sequence=BAA04801.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the clathrin heavy chain family. {ECO:0000305}.
Similarity	Contains 7 CHCR (clathrin heavy-chain) repeats. {ECO:0000255\|PROSITE-ProRule:PRU01006}.
Subcellular Location	Cytoplasmic vesicle membrane {ECO:0000269\|PubMed:17081065}; Peripheral membrane protein {ECO:0000269\|PubMed:17081065}; Cytoplasmic side {ECO:0000269\|PubMed:17081065}. Membrane, coated pit {ECO:0000269\|PubMed:17081065}; Peripheral membrane protein {ECO:0000269\|PubMed:17081065}; Cytoplasmic side {ECO:0000269\|PubMed:17081065}. Melanosome {ECO:0000269\|PubMed:17081065}. Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Subunit	Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium. Interacts with HIP1. Interacts with DENND1A, DENND1B and DENND1C (By similarity). May interact with OCRL. Interacts with ERBB2 (By similarity). Interacts with FKBP6. {ECO:0000250, ECO:0000269\|PubMed:11532990, ECO:0000269\|PubMed:16314522, ECO:0000269\|PubMed:18529014, ECO:0000269\|PubMed:21816279}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CLTCID360.html";
Web Resource	Name=Wikipedia; Note=Clathrin entry; URL="http://en.wikipedia.org/wiki/Clathrin";