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MT000142

UniProt Annotations

Entry Information

Gene Name	COX11 cytochrome c oxidase copper chaperone
Protein Entry	COX11_HUMAN
UniProt ID	Q9Y6N1
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y6N1-1; Sequence=Displayed; Name=2; IsoId=Q9Y6N1-2; Sequence=VSP_046360; Note=No experimental confirmation available. Ref.4 (BI600359) sequence is in conflict in position: 223:V->G. {ECO:0000305};
Function	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. {ECO:0000250}.
Similarity	Belongs to the COX11/CtaG family. {ECO:0000305}.
Subcellular Location	Mitochondrion inner membrane {ECO:0000269\|PubMed:9878253}; Single-pass membrane protein {ECO:0000269\|PubMed:9878253}; Intermembrane side {ECO:0000269\|PubMed:9878253}.
Subunit	Interacts with CNNM4/ACDP4. {ECO:0000269\|PubMed:15840172}.
Tissue Specificity	Ubiquitous. {ECO:0000269\|PubMed:9878253}.