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MitoProteome Human Mitochondrial Protein Database
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Related Proteins
MT000157
UniProt Annotations
Entry Information
Gene Name
cathepsin B
Protein Entry
CATB_HUMAN
UniProt ID
P07858
Species
Human
Comments
Comment type
Description
Catalytic Activity
Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.
Function
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
Interaction
Q6UY14:ADAMTSL4; NbExp=3; IntAct=EBI-715062, EBI-742002; P02760:AMBP; NbExp=4; IntAct=EBI-715062, EBI-2115136; P40692:MLH1; NbExp=7; IntAct=EBI-715062, EBI-744248; Q9NYA1:SPHK1; NbExp=4; IntAct=EBI-715062, EBI-985303;
Similarity
Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-ProRule:PRU10088, ECO:0000255|PROSITE- ProRule:PRU10089, ECO:0000255|PROSITE-ProRule:PRU10090}.
Subcellular Location
Lysosome. Melanosome. Secreted, extracellular space {ECO:0000250}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Subunit
Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. {ECO:0000269|PubMed:18718938}.
Web Resource
Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CTSBID40202ch8p23.html";
MitoProteome Human Mitochondrial Protein Database
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