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MT000160

Record overview

MITO IDMT000160
Gene ID1535
SpeciesHomo sapiens (Human)
Gene Namecytochrome b-245, alpha polypeptide
Gene SymbolCYBA
Synonymsp22-PHOX;
Alternate namescytochrome b-245 light chain; p22phox; cytochrome b light chain; p22 phagocyte B-cytochrome; cytochrome b(558) alpha chain; cytochrome b558 subunit alpha; cytochrome b(558) alpha-subunit; cytochrome b, alpha polypeptide; flavocytochrome b-558 alpha polypeptide; neutrophil cytochrome b 22 kDa polypeptide; superoxide-generating NADPH oxidase light chain subunit;
Chromosome16
Map Location16q24
SummaryCytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CYBA

Proteins

cytochrome b-245 light chain
Refseq ID:NP_000092
Protein GI:68509914
UniProt ID:P13498
mRNA ID:NM_000101
Length:195
RefSeq Status:
MGQIEWAMWANEQALASGLILITGGIVATAGRFTQWYFGAYSIVAGVFVCLLEYPRGKRKKGSTMERWGQKYMTAVVKLFGPFTRNYYVRAVLHLLLSVP
AGFLLATILGTACLAIASGIYLLAAVRGEQWTPIEPKPRERPQIGGTIKQPPSNPPPRPPAEARKKPSEEEAAVAAGGPPGGPQVNPIPVTDEVV