MitoProteome Database

MT000163

Gene Information

Entrez Gene ID	1543
Gene Name	cytochrome P450, family 1, subfamily A, polypeptide 1
Gene Symbol	CYP1A1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005789	TAS:Reactome	C	endoplasmic reticulum membrane
GO:0005739	IEA:Ensembl	C	mitochondrion
GO:0070330	IEA:UniProtKB-EC	F	aromatase activity
GO:0032451	IEA:Ensembl	F	demethylase activity
GO:0016711	IEA:Ensembl	F	flavonoid 3'-monooxygenase activity
GO:0020037	IEA:InterPro	F	heme binding
GO:0005506	IEA:InterPro	F	iron ion binding
GO:0016491	IDA:BHF-UCL	F	oxidoreductase activity
GO:0016679	IEA:Ensembl	F	oxidoreductase activity, acting on diphenols and related substances as donors
GO:0019825	TAS:ProtInc	F	oxygen binding
GO:0008395	IEA:Ensembl	F	steroid hydroxylase activity
GO:0070576	IDA:BHF-UCL	F	vitamin D 24-hydroxylase activity
GO:0042904	IEA:Ensembl	P	9-cis-retinoic acid biosynthetic process
GO:0007568	IEA:Ensembl	P	aging
GO:0009308	IEA:Ensembl	P	amine metabolic process
GO:0019369	TAS:Reactome	P	arachidonic acid metabolic process
GO:0043010	IEA:Ensembl	P	camera-type eye development
GO:0008283	IEA:Ensembl	P	cell proliferation
GO:0044255	TAS:Reactome	P	cellular lipid metabolic process
GO:0071407	IDA:MGI	P	cellular response to organic cyclic compound
GO:0009804	IEA:Ensembl	P	coumarin metabolic process
GO:0019341	IEA:Ensembl	P	dibenzo-p-dioxin catabolic process
GO:0048565	IEA:Ensembl	P	digestive tract development
GO:0017144	IDA:BHF-UCL	P	drug metabolic process
GO:0009792	IEA:Ensembl	P	embryo development ending in birth or egg hatching
GO:0019373	TAS:Reactome	P	epoxygenase P450 pathway
GO:0009812	IEA:Ensembl	P	flavonoid metabolic process
GO:0070365	IEA:Ensembl	P	hepatocyte differentiation
GO:0050665	IEA:Ensembl	P	hydrogen peroxide biosynthetic process
GO:0017143	IEA:Ensembl	P	insecticide metabolic process
GO:0060137	IEA:Ensembl	P	maternal process involved in parturition
GO:0097267	TAS:Reactome	P	omega-hydroxylase P450 pathway
GO:0055114	IDA:BHF-UCL	P	oxidation-reduction process
GO:0006778	IEA:Ensembl	P	porphyrin-containing compound metabolic process
GO:1900087	IEA:Ensembl	P	positive regulation of G1/S transition of mitotic cell cycle
GO:0046677	IEA:Ensembl	P	response to antibiotic
GO:0046685	IEA:Ensembl	P	response to arsenic-containing substance
GO:0042493	IEA:Ensembl	P	response to drug
GO:0032094	IEA:Ensembl	P	response to food
GO:0009635	IEA:Ensembl	P	response to herbicide
GO:0055093	IEA:Ensembl	P	response to hyperoxia
GO:0001666	IEA:Ensembl	P	response to hypoxia
GO:0010041	IEA:Ensembl	P	response to iron(III) ion
GO:0032496	IEA:Ensembl	P	response to lipopolysaccharide
GO:0009624	IEA:Ensembl	P	response to nematode
GO:0009615	IEA:Ensembl	P	response to virus
GO:0033189	IEA:Ensembl	P	response to vitamin A
GO:0009611	IEA:Ensembl	P	response to wounding
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0042359	IC:BHF-UCL	P	vitamin D metabolic process
GO:0006805	TAS:Reactome	P	xenobiotic metabolic process

KEGG Pathway Links

KEGG Pathway ID	Description
hsa05204	Chemical carcinogenesis
ko05204	Chemical carcinogenesis
hsa01100	Metabolic pathways
hsa00980	Metabolism of xenobiotics by cytochrome P450
ko00980	Metabolism of xenobiotics by cytochrome P450
hsa04913	Ovarian steroidogenesis
ko04913	Ovarian steroidogenesis
hsa00830	Retinol metabolism
ko00830	Retinol metabolism
hsa00140	Steroid hormone biosynthesis
ko00140	Steroid hormone biosynthesis
hsa00380	Tryptophan metabolism
ko00380	Tryptophan metabolism

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_147851	Arachidonic acid metabolism
REACT_13433	Biological oxidations
REACT_13567	Cytochrome P450 - arranged by substrate type
REACT_22279	Fatty acid, triacylglycerol, and ketone body metabolism
REACT_111217	Metabolism
REACT_22258	Metabolism of lipids and lipoproteins
REACT_13705	Phase 1 - Functionalization of compounds
REACT_116145	PPARA activates gene expression
REACT_19241	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_150134	Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
REACT_150417	Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
REACT_13543	Xenobiotics