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MT000163

UniProt Annotations

Entry Information

Gene Name	cytochrome P450, family 1, subfamily A, polypeptide 1
Protein Entry	CP1A1_HUMAN
UniProt ID	P04798
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P04798-1; Sequence=Displayed; Name=2; IsoId=P04798-2; Sequence=VSP_053364, VSP_053365; Note=No experimental confirmation available.; Name=3; IsoId=P04798-3; Sequence=VSP_053363, VSP_053366; Note=No experimental confirmation available.;
Catalytic Activity	RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.
Cofactor	Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000269\|PubMed:23508959};
Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Induction	By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Similarity	Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue Specificity	Lung, lymphocytes and placenta.
Web Resource	Name=Cytochrome P450 Allele Nomenclature Committee; Note=CYP1A1 alleles; URL="http://www.cypalleles.ki.se/cyp1a1.htm";
Web Resource	Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=CYP1A1";
Web Resource	Name=Wikipedia; Note=CYP1A1 entry; URL="http://en.wikipedia.org/wiki/CYP1A1";