MitoProteome Database

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MT000164

Gene Information

Entrez Gene ID1545
Gene Namecytochrome P450, family 1, subfamily B, polypeptide 1
Gene SymbolCYP1B1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0005739 ISS:UniProtKBCmitochondrion
GO:0070330 IEA:UniProtKB-ECFaromatase activity
GO:0020037 IDA:UniProtKBFheme binding
GO:0005506 IEA:InterProFiron ion binding
GO:0004497 IDA:UniProtKBFmonooxygenase activity
GO:0016712 IDA:MGIFoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825 TAS:UniProtKBFoxygen binding
GO:0001525 IEA:EnsemblPangiogenesis
GO:0019369 IDA:UniProtKBParachidonic acid metabolic process
GO:0048514 ISS:UniProtKBPblood vessel morphogenesis
GO:0007155 ISS:UniProtKBPcell adhesion
GO:0006725 IEA:EnsemblPcellular aromatic compound metabolic process
GO:0070301 ISS:UniProtKBPcellular response to hydrogen peroxide
GO:0071407 IDA:MGIPcellular response to organic cyclic compound
GO:0030199 ISS:UniProtKBPcollagen fibril organization
GO:0071603 IEA:EnsemblPendothelial cell-cell adhesion
GO:0043542 ISS:UniProtKBPendothelial cell migration
GO:0019373 TAS:ReactomePepoxygenase P450 pathway
GO:0008210 IDA:UniProtKBPestrogen metabolic process
GO:0008631 ISS:UniProtKBPintrinsic apoptotic signaling pathway in response to oxidative stress
GO:0046466 ISS:UniProtKBPmembrane lipid catabolic process
GO:0033629 ISS:UniProtKBPnegative regulation of cell adhesion mediated by integrin
GO:0030336 ISS:UniProtKBPnegative regulation of cell migration
GO:0008285 ISS:UniProtKBPnegative regulation of cell proliferation
GO:0032088 ISS:UniProtKBPnegative regulation of NF-kappaB transcription factor activity
GO:0006809 ISS:UniProtKBPnitric oxide biosynthetic process
GO:0097267 TAS:ReactomePomega-hydroxylase P450 pathway
GO:0055114 TAS:UniProtKBPoxidation-reduction process
GO:0045766 ISS:UniProtKBPpositive regulation of angiogenesis
GO:0043065 ISS:UniProtKBPpositive regulation of apoptotic process
GO:1901313 ISS:UniProtKBPpositive regulation of gene expression involved in extracellular matrix organization
GO:0046427 ISS:UniProtKBPpositive regulation of JAK-STAT cascade
GO:0010575 ISS:UniProtKBPpositive regulation vascular endothelial growth factor production
GO:2000377 ISS:UniProtKBPregulation of reactive oxygen species metabolic process
GO:0009636 IEA:EnsemblPresponse to toxic substance
GO:0061304 ISS:UniProtKBPretinal blood vessel morphogenesis
GO:0042574 IDA:UniProtKBPretinal metabolic process
GO:0042572 IDA:UniProtKBPretinol metabolic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0008202 IDA:UniProtKBPsteroid metabolic process
GO:0016125 TAS:ReactomePsterol metabolic process
GO:0009404 IEA:EnsemblPtoxin metabolic process
GO:0002930 ISS:UniProtKBPtrabecular meshwork development
GO:0007601 TAS:UniProtKBPvisual perception
GO:0006805 IDA:UniProtKBPxenobiotic metabolic process
KEGG Pathway Links
KEGG Pathway IDDescription
hsa05204Chemical carcinogenesis
ko05204Chemical carcinogenesis
hsa00980Metabolism of xenobiotics by cytochrome P450
ko00980Metabolism of xenobiotics by cytochrome P450
hsa05206MicroRNAs in cancer
ko05206MicroRNAs in cancer
hsa04913Ovarian steroidogenesis
ko04913Ovarian steroidogenesis
hsa00140Steroid hormone biosynthesis
ko00140Steroid hormone biosynthesis
hsa00380Tryptophan metabolism
ko00380Tryptophan metabolism
BIOCYC Pathway Links
BIOCYC Pathway IDDescription
PWY-6398melatonin degradation I
PWY-6398melatonin degradation I
PWY-6402superpathway of melatonin degradation
PWY-6402superpathway of melatonin degradation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_147851Arachidonic acid metabolism
REACT_13433Biological oxidations
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_13812Endogenous sterols
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_13705Phase 1 - Functionalization of compounds
REACT_150134Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
REACT_150417Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)