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MT000165

UniProt Annotations

Entry Information

Gene Name	cytochrome P450, family 2, subfamily D, polypeptide 6
Protein Entry	CP2D6_HUMAN
UniProt ID	P10635
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P10635-1; Sequence=Displayed; Name=2; IsoId=P10635-2; Sequence=VSP_044486; Note=No experimental confirmation available.;
Catalytic Activity	RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.
Cofactor	Name=heme; Xref=ChEBI:CHEBI:30413;
Function	Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. {ECO:0000269\|PubMed:16352597}.
Induction	By pregnancy.
Polymorphism	Allele CYP2D67 was also known as CYP2D6E, allele CYP2D69 as CYP2D6C, allele CYP2D610 as CYP2D6J, allele CYP2D617 as CYP2D6Z.
Polymorphism	Genetic variations in CYP2D6 are the cause of poor drug metabolism CYP2D6-related [MIM:608902]. The CYP2D6 gene is highly polymorphic. CYP2D6 activity ranges widely within a population comprising ultrarapid (UM), extensive (EM), intermediate (IM) and poor (PM) metabolizer phenotypes. UM and PM are those most at risk for treatment failure or dose-dependent drug toxicity, respectively. Of the Caucasian populations of Europe and North America, 5%-10% are of the PM phenotype and are unable to metabolize the antihypersensitive drug debrisoquine and numerous other drugs.
Polymorphism	Isozymes CYP2D6.45 (Lys-155, Cys-296 and Thr-486) and CYP2D6.46 (His-26, Lys-155, Cys-296 and Thr-486) are functional.
Similarity	Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Web Resource	Name=Cytochrome P450 Allele Nomenclature Committee; Note=CYP2D6 alleles; URL="http://www.cypalleles.ki.se/cyp2d6.htm";
Web Resource	Name=Wikipedia; Note=CYP2D6 entry; URL="http://en.wikipedia.org/wiki/CYP2D6";