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MitoProteome Human Mitochondrial Protein Database
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Related Proteins
MT000166
UniProt Annotations
Entry Information
Gene Name
cytochrome P450, family 2, subfamily E, polypeptide 1
Protein Entry
CP2E1_HUMAN
UniProt ID
P05181
Species
Human
Comments
Comment type
Description
Catalytic Activity
4-nitrophenol + NADPH + O(2) = 4-nitrocatechol + NADP(+) + H(2)O. {ECO:0000269|PubMed:9348445}.
Cofactor
Name=heme; Xref=ChEBI:CHEBI:30413;
Function
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Induction
By ethanol and isoniazid.
Similarity
Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Web Resource
Name=Cytochrome P450 Allele Nomenclature Committee; Note=CYP2E1 alleles; URL="http://www.cypalleles.ki.se/cyp2e1.htm";
Web Resource
Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cyp2e1/";
Web Resource
Name=Wikipedia; Note=CYP2E1 entry; URL="http://en.wikipedia.org/wiki/CYP2E1";
MitoProteome Human Mitochondrial Protein Database
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