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MT000174

Record overview

MITO IDMT000174
Gene ID1610
SpeciesHomo sapiens (Human)
Gene NameD-amino-acid oxidase
Gene SymbolDAO
SynonymsDAAO; OXDA; DAMOX;
Alternate namesD-amino-acid oxidase; D-amino acid oxidase;
Chromosome12
Map Location12q24
EC Number1.4.3.3;
SummaryThis gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for DAO

Proteins

D-amino-acid oxidase
Refseq ID:NP_001908
Protein GI:148539837
UniProt ID:P14920
mRNA ID:NM_001917
Length:347
RefSeq Status:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHE
AIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRG
QIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGP
SNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL