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MT000174

UniProt Annotations

Entry Information

Gene Name	D-amino-acid oxidase
Protein Entry	OXDA_HUMAN
UniProt ID	P14920
Species	Human

Comments

Comment type	Description
Biophysicochemical Properties	Kinetic parameters: KM=3.6 mM for D-serine {ECO:0000269\|PubMed:17088322, ECO:0000269\|PubMed:17303072}; KM=1.7 mM for D-proline {ECO:0000269\|PubMed:17088322, ECO:0000269\|PubMed:17303072}; KM=1.1 mM for D-tyrosine {ECO:0000269\|PubMed:17088322, ECO:0000269\|PubMed:17303072}; KM=1.5 mM for D-DOPA {ECO:0000269\|PubMed:17088322, ECO:0000269\|PubMed:17303072}; KM=1.2 mM for D-phenylalanine {ECO:0000269\|PubMed:17088322, ECO:0000269\|PubMed:17303072}; KM=0.9 mM for D-alanine {ECO:0000269\|PubMed:17088322, ECO:0000269\|PubMed:17303072};
Catalytic Activity	A D-amino acid + H(2)O + O(2) = a 2-oxo acid + NH(3) + H(2)O(2). {ECO:0000269\|PubMed:17088322}.
Cofactor	Name=FAD; Xref=ChEBI:CHEBI:57692;
Function	Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D- amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. {ECO:0000269\|PubMed:17303072}.
Similarity	Belongs to the DAMOX/DASOX family. {ECO:0000305}.
Subcellular Location	Peroxisome.
Subunit	Homodimer. {ECO:0000269\|PubMed:17088322, ECO:0000269\|PubMed:18455394}.