MitoProteome Database

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MT000175

Record overview

MITO IDMT000175
Gene ID1622
SpeciesHomo sapiens (Human)
Gene Namediazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
Gene SymbolDBI
SynonymsEP; ACBP; ACBD1; CCK-RP;
Alternate namesacyl-CoA-binding protein; endozepine; GABA receptor modulator; diazepam-binding inhibitor; acyl coenzyme A binding protein; acyl-Coenzyme A binding domain containing 1; cholecystokinin-releasing peptide, trypsin-sensitive; diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein);
Chromosome2
Map Location2q12-q21
SummaryThis gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for DBI

Proteins

acyl-CoA-binding protein isoform 1
Refseq ID:NP_065438
Protein GI:10140853
UniProt ID:P07108
mRNA ID:NM_020548
Length:104
RefSeq Status:
MWGDLWLLPPASANPGTGTEAEFEKAAEEVRHLKTKPSDEEMLFIYGHYKQATVGDINTERPGMLDFTGKAKWDAWNELKGTSKEDAMKAYINKVEELKK
KYGI
 
acyl-CoA-binding protein isoform 1
Refseq ID:NP_001171513
Protein GI:295849279
UniProt ID:P07108
mRNA ID:NM_001178042
Length:104
RefSeq Status:
Protein sequence is identical to GI:10140853 (mRNA isoform)
 
acyl-CoA-binding protein isoform 1
Refseq ID:NP_001269562
Protein GI:544063478
UniProt ID:P07108
mRNA ID:NM_001282633
Length:104
RefSeq Status:
Protein sequence is identical to GI:10140853 (mRNA isoform)
 
acyl-CoA-binding protein isoform 1
Refseq ID:NP_001269564
Protein GI:544063480
UniProt ID:P07108
mRNA ID:NM_001282635
Length:104
RefSeq Status:
Protein sequence is identical to GI:10140853 (mRNA isoform)
 
acyl-CoA-binding protein isoform 1
Refseq ID:NP_001269563
Protein GI:544063482
UniProt ID:P07108
mRNA ID:NM_001282634
Length:104
RefSeq Status:
Protein sequence is identical to GI:10140853 (mRNA isoform)
 
acyl-CoA-binding protein isoform 2
Refseq ID:NP_001073332
Protein GI:120433593
UniProt ID:P07108
mRNA ID:NM_001079863
Length:88
RefSeq Status:
MPAFAEFEKAAEEVRHLKTKPSDEEMLFIYGHYKQATVGDINTERPGMLDFTGKAKWDAWNELKGTSKEDAMKAYINKVEELKKKYGI
 
acyl-CoA-binding protein isoform 3
Refseq ID:NP_001073331
Protein GI:120433590
UniProt ID:P07108
mRNA ID:NM_001079862
Length:87
RefSeq Status:
MSQAEFEKAAEEVRHLKTKPSDEEMLFIYGHYKQATVGDINTERPGMLDFTGKAKWDAWNELKGTSKEDAMKAYINKVEELKKKYGI
 
acyl-CoA-binding protein isoform 4
Refseq ID:NP_001171488
Protein GI:295849266
UniProt ID:P07108
mRNA ID:NM_001178017
Length:148
RefSeq Status:
MERWGKGLHGLEERGDSVPIPKHRAGRRGGVGKRGVRGRELGGQGKYGAGCSECGTRRIAARGEAEFEKAAEEVRHLKTKPSDEEMLFIYGHYKQATVGD
INTERPGMLDFTGKAKWDAWNELKGTSKEDAMKAYINKVEELKKKYGI
 
acyl-CoA-binding protein isoform 5
Refseq ID:NP_001171512
Protein GI:295842514
UniProt ID:P07108
mRNA ID:NM_001178041
Length:129
RefSeq Status:
MSQHRAGRRGGVGKRGVRGRELGGQGKYGAGCSECGTRRIAARGEAEFEKAAEEVRHLKTKPSDEEMLFIYGHYKQATVGDINTERPGMLDFTGKAKWDA
WNELKGTSKEDAMKAYINKVEELKKKYGI
 
acyl-CoA-binding protein isoform 6
Refseq ID:NP_001171514
Protein GI:295842534
UniProt ID:B8ZWD1
mRNA ID:NM_001178043
Length:97
RefSeq Status:
MSQVQRVHSQAAKAEFEKAAEEVRHLKTKPSDEEMLFIYGHYKQATVGDINTERPGMLDFTGKAKWDAWNELKGTSKEDAMKAYINKVEELKKKYGI
 
acyl-CoA-binding protein isoform 7
Refseq ID:NP_001269565
Protein GI:544063486
UniProt ID:B8ZWD8
mRNA ID:NM_001282636
Length:63
RefSeq Status:
MLFIYGHYKQATVGDINTERPGMLDFTGKAKWDAWNELKGTSKEDAMKAYINKVEELKKKYGI