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MT000175

UniProt Annotations

Entry Information

Gene Name	diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
Protein Entry	ACBP_HUMAN
UniProt ID	P07108
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative promoter usage, Alternative splicing; Named isoforms=6; Name=1; Synonyms=ACBP-1a, Short; IsoId=P07108-1; Sequence=Displayed; Name=2; Synonyms=ACBP-1b, Long; IsoId=P07108-2; Sequence=VSP_000068; Name=3; Synonyms=ACBP-1c; IsoId=P07108-3; Sequence=VSP_038680; Name=4; Synonyms=ACBP-1a1-g; IsoId=P07108-4; Sequence=VSP_043437; Name=5; Synonyms=ACBP-1g; IsoId=P07108-5; Sequence=VSP_043438; Name=6; Synonyms=ACBP-1e; IsoId=P07108-6; Sequence=VSP_044114; Note=Predominantly expressed in adipose tissue and hippocampus.;
Function	Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
Similarity	Belongs to the ACBP family. {ECO:0000305}.
Similarity	Contains 1 ACB (acyl-CoA-binding) domain. {ECO:0000255\|PROSITE-ProRule:PRU00573}.
Subcellular Location	Endoplasmic reticulum. Golgi apparatus. Note=Golgi localization is dependent on ligand binding.
Subunit	Monomer. {ECO:0000269\|PubMed:17044054}.
Tissue Specificity	Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart. {ECO:0000269\|PubMed:16055366, ECO:0000269\|PubMed:21698759}.