MitoProteome Database

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MT000187

Gene Information

Entrez Gene ID1743
Gene Namedihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
Gene SymbolDLST
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0070062 IDA:UniProtCextracellular vesicular exosome
GO:0016020 IDA:UniProtKBCmembrane
GO:0005759 TAS:ReactomeCmitochondrial matrix
GO:0005634 IDA:UniProtCnucleus
GO:0045252 IEA:InterProCoxoglutarate dehydrogenase complex
GO:0004149 IEA:UniProtKB-ECFdihydrolipoyllysine-residue succinyltransferase activity
GO:0044237 TAS:ReactomePcellular metabolic process
GO:0034641 TAS:ReactomePcellular nitrogen compound metabolic process
GO:0006091 TAS:ProtIncPgeneration of precursor metabolites and energy
GO:0033512 IEA:UniProtKB-UniPathwayPL-lysine catabolic process to acetyl-CoA via saccharopine
GO:0006554 TAS:ReactomePlysine catabolic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006099 TAS:ReactomePtricarboxylic acid cycle
KEGG Pathway Links
KEGG Pathway IDDescription
hsa01200Carbon metabolism
ko01200Carbon metabolism
hsa_M00011Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00011Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
hsa00020Citrate cycle (TCA cycle)
ko00020Citrate cycle (TCA cycle)
hsa_M00009Citrate cycle (TCA cycle, Krebs cycle)
M00009Citrate cycle (TCA cycle, Krebs cycle)
hsa00310Lysine degradation
ko00310Lysine degradation
hsa_M00032Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00032Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
hsa01100Metabolic pathways
BIOCYC Pathway Links
BIOCYC Pathway IDDescription
PWY-50842-oxoglutarate decarboxylation to succinyl-CoA
PWY-50842-oxoglutarate decarboxylation to succinyl-CoA
PWY-5690TCA cycle II (eukaryotic)
PWY66-398TCA cycle VIII (metazoan)
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_1785Citric acid cycle (TCA cycle)
REACT_1298Lysine catabolism
REACT_111217Metabolism
REACT_13Metabolism of amino acids and derivatives
REACT_1046Pyruvate metabolism and Citric Acid (TCA) cycle
REACT_111083The citric acid (TCA) cycle and respiratory electron transport