MitoProteome Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins

MT000187

UniProt Annotations

Entry Information

Gene Name	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
Protein Entry	ODO2_HUMAN
UniProt ID	P36957
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P36957-1; Sequence=Displayed; Name=2; IsoId=P36957-2; Sequence=VSP_056439, VSP_056440; Note=No experimental confirmation available.;
Catalytic Activity	Succinyl-CoA + enzyme N(6)- (dihydrolipoyl)lysine = CoA + enzyme N(6)-(S- succinyldihydrolipoyl)lysine.
Cofactor	Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Note=Binds 1 lipoyl cofactor covalently.;
Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
Pathway	Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.
Similarity	Belongs to the 2-oxoacid dehydrogenase family. {ECO:0000305}.
Similarity	Contains 1 lipoyl-binding domain. {ECO:0000255\|PROSITE-ProRule:PRU01066, ECO:0000305}.
Subcellular Location	Mitochondrion.
Subunit	Forms a 24-polypeptide structural core with octahedral symmetry.