MitoProteome Database

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MT000196

Gene Information

Entrez Gene ID1869
Gene NameE2F transcription factor 1
Gene SymbolE2F1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IEA:EnsemblCcytoplasm
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0035189 IDA:BHF-UCLCRb-E2F complex
GO:0001047 IDA:UniProtKBFcore promoter binding
GO:0003677 IDA:UniProtKBFDNA binding
GO:0043565 IEA:EnsemblFsequence-specific DNA binding
GO:0003700 IDA:UniProtKBFsequence-specific DNA binding transcription factor activity
GO:0008134 IPI:UniProtKBFtranscription factor binding
GO:0043276 IEA:EnsemblPanoikis
GO:0006915 TAS:ReactomePapoptotic process
GO:0071398 IEA:EnsemblPcellular response to fatty acid
GO:0071456 IEA:EnsemblPcellular response to hypoxia
GO:0000077 IMP:UniProtKBPDNA damage checkpoint
GO:0030900 IEA:EnsemblPforebrain development
GO:0000082 TAS:ReactomePG1/S transition of mitotic cell cycle
GO:0097193 TAS:ReactomePintrinsic apoptotic signaling pathway
GO:0072332 IEA:EnsemblPintrinsic apoptotic signaling pathway by p53 class mediator
GO:0008630 IMP:UniProtKBPintrinsic apoptotic signaling pathway in response to DNA damage
GO:1990086 IEA:EnsemblPlens fiber cell apoptotic process
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0048255 IDA:BHF-UCLPmRNA stabilization
GO:0045892 IMP:BHF-UCLPnegative regulation of transcription, DNA-templated
GO:0000122 IMP:BHF-UCLPnegative regulation of transcription from RNA polymerase II promoter
GO:0071930 IMP:BHF-UCLPnegative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0007219 TAS:ReactomePNotch signaling pathway
GO:0048146 IMP:BHF-UCLPpositive regulation of fibroblast proliferation
GO:0010628 IDA:BHF-UCLPpositive regulation of gene expression
GO:1900740 TAS:ReactomePpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0045893 IMP:BHF-UCLPpositive regulation of transcription, DNA-templated
GO:0045944 IMP:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:2000045 IMP:BHF-UCLPregulation of G1/S transition of mitotic cell cycle
GO:0006355 IDA:UniProtKBPregulation of transcription, DNA-templated
GO:0007283 IEA:EnsemblPspermatogenesis
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
KEGG Pathway Links
KEGG Pathway IDDescription
hsa05219Bladder cancer
ko05219Bladder cancer
hsa04110Cell cycle
ko04110Cell cycle
hsa05220Chronic myeloid leukemia
ko05220Chronic myeloid leukemia
hsa05214Glioma
ko05214Glioma
hsa05161Hepatitis B
hsa05166HTLV-I infection
ko05166HTLV-I infection
hsa05218Melanoma
ko05218Melanoma
hsa05206MicroRNAs in cancer
ko05206MicroRNAs in cancer
hsa05223Non-small cell lung cancer
ko05223Non-small cell lung cancer
hsa05212Pancreatic cancer
ko05212Pancreatic cancer
hsa05200Pathways in cancer
hsa05215Prostate cancer
ko05215Prostate cancer
hsa05222Small cell lung cancer
ko05222Small cell lung cancer
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_697Activation of BH3-only proteins
REACT_1194Activation of NOXA and translocation to mitochondria
REACT_121Activation of PUMA and translocation to mitochondria
REACT_578Apoptosis
REACT_2243Assembly of the pre-replicative complex
REACT_1181Association of licensing factors with the pre-replicative complex
REACT_1707CDC6 association with the ORC:origin complex
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_821Cyclin D associated events in G1
REACT_383DNA Replication
REACT_734DNA Replication Pre-Initiation
REACT_471E2F mediated regulation of DNA replication
REACT_111214G0 and Early G1
REACT_1590G1 Phase
REACT_683G1/S-Specific Transcription
REACT_1783G1/S Transition
REACT_1915G2 Phase
REACT_329Inhibition of replication initiation of damaged DNA by RB1/E2F1
REACT_964Intrinsic Pathway for Apoptosis
REACT_1725M/G1 Transition
REACT_21267Mitotic G1-G1/S phases
REACT_21391Mitotic G2-G2/M phases
REACT_169325Oncogene Induced Senescence
REACT_169436Oxidative Stress Induced Senescence
REACT_118744Pre-NOTCH Expression and Processing
REACT_118568Pre-NOTCH Transcription and Translation
REACT_829Regulation of DNA replication
REACT_299Signaling by NOTCH
REACT_111102Signal Transduction