MitoProteome Database

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MT000216

Gene Information

Entrez Gene ID2180
Gene Nameacyl-CoA synthetase long-chain family member 1
Gene SymbolACSL1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0016020 IDA:UniProtKBCmembrane
GO:0005741 TAS:ReactomeCmitochondrial outer membrane
GO:0005739 IDA:UniProtKBCmitochondrion
GO:0005778 IEA:EnsemblCperoxisomal membrane
GO:0005886 IEA:EnsemblCplasma membrane
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0004467 IDA:UniProtKBFlong-chain fatty acid-CoA ligase activity
GO:0033211 IEA:EnsemblPadiponectin-activated signaling pathway
GO:0036109 TAS:ReactomePalpha-linolenic acid metabolic process
GO:0044255 TAS:ReactomePcellular lipid metabolic process
GO:0043651 TAS:ReactomePlinoleic acid metabolic process
GO:0008610 IDA:UniProtKBPlipid biosynthetic process
GO:0044539 IDA:UniProtKBPlong-chain fatty acid import
GO:0001676 IDA:UniProtKBPlong-chain fatty acid metabolic process
GO:0035338 TAS:ReactomePlong-chain fatty-acyl-CoA biosynthetic process
GO:0071902 IEA:EnsemblPpositive regulation of protein serine/threonine kinase activity
GO:0042493 IEA:EnsemblPresponse to drug
GO:0007584 IEA:EnsemblPresponse to nutrient
GO:0034201 IEA:EnsemblPresponse to oleic acid
GO:0014070 IEA:EnsemblPresponse to organic cyclic compound
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0019432 TAS:ReactomePtriglyceride biosynthetic process
GO:0033559 TAS:ReactomePunsaturated fatty acid metabolic process
GO:0042178 IEA:EnsemblPxenobiotic catabolic process
KEGG Pathway Links
KEGG Pathway IDDescription
hsa04920Adipocytokine signaling pathway
ko04920Adipocytokine signaling pathway
hsa_M00086beta-Oxidation, acyl-CoA synthesis
M00086beta-Oxidation, acyl-CoA synthesis
hsa00061Fatty acid biosynthesis
ko00061Fatty acid biosynthesis
hsa00071Fatty acid degradation
ko00071Fatty acid degradation
hsa01212Fatty acid metabolism
ko01212Fatty acid metabolism
hsa01100Metabolic pathways
hsa04146Peroxisome
ko04146Peroxisome
hsa03320PPAR signaling pathway
ko03320PPAR signaling pathway
BIOCYC Pathway Links
BIOCYC Pathway IDDescription
PWY-7049eicosapentaenoate biosynthesis II (metazoa)
PWY-7049eicosapentaenoate biosynthesis II (metazoa)
PWY-5143fatty acid activation
PWY66-387fatty acid alpha-oxidation II
FAO-PWYfatty acid beta-oxidation I
FAO-PWYfatty acid beta-oxidation I
PWY66-391fatty acid beta-oxidation VI (peroxisome)
PWY-6000gamma-linolenate biosynthesis II (animals)
PWY-6000gamma-linolenate biosynthesis II (animals)
PWY-5972stearate biosynthesis I (animals)
PWY-5972stearate biosynthesis I (animals)
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_121147alpha-linolenic acid (ALA) metabolism
REACT_121284alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_1319Fatty Acyl-CoA Biosynthesis
REACT_121100Linoleic acid (LA) metabolism
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_116145PPARA activates gene expression
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_380Synthesis of very long-chain fatty acyl-CoAs
REACT_1190Triglyceride Biosynthesis