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MT000216

UniProt Annotations

Entry Information

Gene Name	acyl-CoA synthetase long-chain family member 1
Protein Entry	ACSL1_HUMAN
UniProt ID	P33121
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P33121-1; Sequence=Displayed; Name=2; IsoId=P33121-2; Sequence=VSP_009604; Note=May be due to a competing acceptor splice site. No experimental confirmation available.; Name=3; IsoId=P33121-3; Sequence=VSP_054391; Note=No experimental confirmation available.;
Catalytic Activity	ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Developmental Stage	Expressed during the early stages of erythroid development while expression is very low in reticulocytes and young erythrocytes.
Function	Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.
Sequence Caution	Sequence=BAC04704.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular Location	Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
Tissue Specificity	Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas. {ECO:0000269\|PubMed:10548543}.