MitoProteome Database

MT000538

Record overview

MITO ID	MT000538
Gene ID	6059
Species	Homo sapiens (Human)
Gene Name	ATP-binding cassette, sub-family E (OABP), member 1
Gene Symbol	ABCE1
Synonyms	RLI; OABP; ABC38; RNS4I; RNASEL1; RNASELI;
Alternate names	ATP-binding cassette sub-family E member 1; huHP68; RNase L inhibitor; ribonuclease 4 inhibitor; 2'-5'-oligoadenylate-binding protein; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor;
Chromosome	4
Map Location	4q31
Summary	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for ABCE1

Proteins

ATP-binding cassette sub-family E member 1

Refseq ID:	NP_002931
Protein GI:	108773782
UniProt ID:	P61221
mRNA ID:	NM_002940
Length:	599
RefSeq Status:

MADKLTRIAIVNHDKCKPKKCRQECKKSCPVVRMGKLCIEVTPQSKIAWISETLCIGCGICIKKCPFGALSIVNLPSNLEKETTHRYCANAFKLHRLPIP
RPGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIV
CQQLDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLSVLDYLSDFICCLYGVPSAYGVVT
MPFSVREGINIFLDGYVPTENLRFRDASLVFKVAETANEEEVKKMCMYKYPGMKKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDE
GGEVPVLNVSYKPQKISPKSTGSVRQLLHEKIRDAYTHPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMA
ARVVKRFILHAKKTAFVVEHDFIMATYLADRVIVFDGVPSKNTVANSPQTLLAGMNKFLSQLEITFRRDPNNYRPRINKLNSIKDVEQKKSGNYFFLDD

ATP-binding cassette sub-family E member 1

Refseq ID:	NP_001035809
Protein GI:	108773784
UniProt ID:	P61221
mRNA ID:	NM_001040876
Length:	599
RefSeq Status:

Protein sequence is identical to GI:108773782 (mRNA isoform)