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MT000538

UniProt Annotations

Entry Information

Gene Name	ATP-binding cassette, sub-family E (OABP), member 1
Protein Entry	ABCE1_HUMAN
UniProt ID	P61221
Species	Human

Comments

Comment type	Description
Function	Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. {ECO:0000269\|PubMed:11585831, ECO:0000269\|PubMed:9660177, ECO:0000269\|PubMed:9847332}.
Induction	Activated by encephalomyocarditis virus (EMCV) and HIV- 1. {ECO:0000269\|PubMed:9660177, ECO:0000269\|PubMed:9847332}.
Miscellaneous	The ABC transporter domains seem not to be functional.
Similarity	Belongs to the ABC transporter superfamily. ABCE family. {ECO:0000305}.
Similarity	Contains 2 4Fe-4S ferredoxin-type domains. {ECO:0000255\|PROSITE-ProRule:PRU00711}.
Similarity	Contains 2 ABC transporter domains. {ECO:0000255\|PROSITE-ProRule:PRU00434}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:11585831}. Mitochondrion {ECO:0000269\|PubMed:11585831}. Note=Localized to clusters of virus formation at the plasma membrane.
Subunit	Probably heterodimerizes with RNASEL; this interaction inhibits the RNASEL. Associates with HIV-1 Vif and HIV-1, HIV-2 and SIV Gag proteins.
Web Resource	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=P61221";
Web Resource	Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/abce1/";