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MT000718

UniProt Annotations

Entry Information

Gene Name	BCL2-associated athanogene 5
Protein Entry	BAG5_HUMAN
UniProt ID	Q9UL15
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UL15-1; Sequence=Displayed; Name=2; IsoId=Q9UL15-2; Sequence=VSP_037996; Note=No experimental confirmation available.;
Domain	The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain. {ECO:0000269\|PubMed:20223214}.
Function	Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. {ECO:0000250, ECO:0000269\|PubMed:20223214}.
Interaction	Q53FC7:-; NbExp=2; IntAct=EBI-356517, EBI-9356749; P08107:HSPA1B; NbExp=6; IntAct=EBI-356517, EBI-629985; Q38SD2:LRRK1; NbExp=3; IntAct=EBI-356517, EBI-1050422; Q5S007:LRRK2; NbExp=12; IntAct=EBI-356517, EBI-5323863;
Sequence Caution	Sequence=BAA74896.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Contains 5 BAG domains. {ECO:0000255\|PROSITE- ProRule:PRU00369}.
Subunit	Binds to the ATPase domain of HSP/HSC70 chaperones. Binds PARK2. {ECO:0000269\|PubMed:20223214}.