MitoProteome Database

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MT000743

UniProt Annotations

Entry Information

Gene Name	BCL2-like 10 (apoptosis facilitator)
Protein Entry	B2L10_HUMAN
UniProt ID	Q9HD36
Species	Human

Comments

Comment type	Description
Function	Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK. {ECO:0000269\|PubMed:11278245}.
Sequence Caution	Sequence=AAG00503.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH93826.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH93828.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI04443.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI04444.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK48715.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the Bcl-2 family. {ECO:0000305}.
Subcellular Location	Mitochondrion {ECO:0000269\|PubMed:11593390}. Nucleus membrane {ECO:0000269\|PubMed:11593390}.
Subunit	Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1. {ECO:0000269\|PubMed:11278245, ECO:0000269\|PubMed:11593390}.
Tissue Specificity	Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney. {ECO:0000269\|PubMed:11593390}.