MitoProteome Database

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MT000744

Record overview

MITO IDMT000744
Gene ID10018
SpeciesHomo sapiens (Human)
Gene NameBCL2-like 11 (apoptosis facilitator)
Gene SymbolBCL2L11
SynonymsBAM; BIM; BOD;
Alternate namesbcl-2-like protein 11; bcl-2 interacting protein Bim; bcl-2-related ovarian death agonist; bcl-2 interacting mediator of cell death;
Chromosome2
Map Location2q13
SummaryThe protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]
OrthologsView orthologs and multiple alignments for BCL2L11

Proteins

bcl-2-like protein 11 isoform 1
Refseq ID:NP_619527
Protein GI:20336315
UniProt ID:O43521
mRNA ID:NM_138621
Length:198
RefSeq Status:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFD
TDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH
 
bcl-2-like protein 11 isoform 10
Refseq ID:NP_996886
Protein GI:46276882
UniProt ID:O43521
mRNA ID:NM_207003
Length:79
RefSeq Status:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRLEK
 
bcl-2-like protein 11 isoform 11
Refseq ID:NP_001191035
Protein GI:323362959
UniProt ID:O43521
mRNA ID:NM_001204106
Length:108
RefSeq Status:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVILRLLRYI
VRLVWRMH
 
bcl-2-like protein 11 isoform 12
Refseq ID:NP_001191036
Protein GI:323362961
UniProt ID:O43521
mRNA ID:NM_001204107
Length:85
RefSeq Status:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRLAKLLASST
 
bcl-2-like protein 11 isoform 13
Refseq ID:NP_001191037
Protein GI:323362963
UniProt ID:O43521
mRNA ID:NM_001204108
Length:172
RefSeq Status:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFD
TDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRMPLPPD
 
bcl-2-like protein 11 isoform 14
Refseq ID:NP_001191038
Protein GI:323362965
UniProt ID:O43521
mRNA ID:NM_001204109
Length:140
RefSeq Status:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFD
TDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMVREIEEVVV
 
bcl-2-like protein 11 isoform 15
Refseq ID:NP_001191039
Protein GI:323362967
UniProt ID:O43521
mRNA ID:NM_001204110
Length:82
RefSeq Status:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRMPLPPD
 
bcl-2-like protein 11 isoform 16
Refseq ID:NP_001191040
Protein GI:323362969
UniProt ID:O43521
mRNA ID:NM_001204111
Length:75
RefSeq Status:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMGIFE
 
bcl-2-like protein 11 isoform 17
Refseq ID:NP_001191041
Protein GI:323362971
UniProt ID:O43521
mRNA ID:NM_001204112
Length:80
RefSeq Status:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMVREIEEVVV
 
bcl-2-like protein 11 isoform 18
Refseq ID:NP_001191042
Protein GI:323362973
UniProt ID:O43521
mRNA ID:NM_001204113
Length:98
RefSeq Status:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMDDSAGSSLRIALHREVQWPLKWLAKSS
 
bcl-2-like protein 11 isoform 2
Refseq ID:NP_619528
Protein GI:20336317
UniProt ID:O43521
mRNA ID:NM_138622
Length:169
RefSeq Status:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFD
TDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRLEK
 
bcl-2-like protein 11 isoform 3
Refseq ID:NP_619529
Protein GI:20336319
UniProt ID:O43521
mRNA ID:NM_138623
Length:109
RefSeq Status:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFN
AYYARRLEK
 
bcl-2-like protein 11 isoform 4
Refseq ID:NP_619530
Protein GI:20336321
UniProt ID:O43521
mRNA ID:NM_138624
Length:135
RefSeq Status:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFD
TDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMANWD
 
bcl-2-like protein 11 isoform 5
Refseq ID:NP_619531
Protein GI:20336323
UniProt ID:O43521
mRNA ID:NM_138625
Length:75
RefSeq Status:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQVSLCHPGWSALVRSWLTATSNSQVQAVLLPQPPK
 
bcl-2-like protein 11 isoform 6
Refseq ID:NP_006529
Protein GI:5729740
UniProt ID:O43521
mRNA ID:NM_006538
Length:138
RefSeq Status:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFN
AYYARRVFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH
 
bcl-2-like protein 11 isoform 7
Refseq ID:NP_619532
Protein GI:20336325
UniProt ID:O43521
mRNA ID:NM_138626
Length:135
RefSeq Status:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFD
TDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMGIFE
 
bcl-2-like protein 11 isoform 8
Refseq ID:NP_619533
Protein GI:20336327
UniProt ID:O43521
mRNA ID:NM_138627
Length:45
RefSeq Status:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGIFE
 
bcl-2-like protein 11 isoform 9
Refseq ID:NP_996885
Protein GI:46276880
UniProt ID:O43521
mRNA ID:NM_207002
Length:112
RefSeq Status:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMVVILEDIGDLSLCFGFIFTGLDLYGHHHS
QDTEQLNHKDFS