MitoProteome Database

MT000744

Gene Information

Entrez Gene ID	10018
Gene Name	BCL2-like 11 (apoptosis facilitator)
Gene Symbol	BCL2L11
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0097141	IDA:UniProtKB	C	BIM-BCL-2 complex
GO:0097140	IDA:UniProtKB	C	BIM-BCL-xl complex
GO:0005829	IDA:UniProtKB	C	cytosol
GO:0019898	IEA:Ensembl	C	extrinsic component of membrane
GO:0005741	TAS:Reactome	C	mitochondrial outer membrane
GO:0006919	IDA:UniProtKB	P	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915	TAS:UniProtKB	P	apoptotic process
GO:1902263	IEA:Ensembl	P	apoptotic process involved in embryonic digit morphogenesis
GO:0097190	TAS:Reactome	P	apoptotic signaling pathway
GO:0001783	IEA:Ensembl	P	B cell apoptotic process
GO:0001782	IEA:Ensembl	P	B cell homeostasis
GO:0007420	IEA:Ensembl	P	brain development
GO:0007160	IEA:Ensembl	P	cell-matrix adhesion
GO:0060154	IEA:Ensembl	P	cellular process regulating host cell cycle in response to virus
GO:0048066	IEA:Ensembl	P	developmental pigmentation
GO:0043583	IEA:Ensembl	P	ear development
GO:0097192	IEA:Ensembl	P	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193	TAS:Reactome	P	intrinsic apoptotic signaling pathway
GO:0008630	IDA:MGI	P	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0001701	IEA:Ensembl	P	in utero embryonic development
GO:0001822	IEA:Ensembl	P	kidney development
GO:0008584	IEA:Ensembl	P	male gonad development
GO:0030879	IEA:Ensembl	P	mammary gland development
GO:0002262	IEA:Ensembl	P	myeloid cell homeostasis
GO:0048011	TAS:Reactome	P	neurotrophin TRK receptor signaling pathway
GO:0042475	IEA:Ensembl	P	odontogenesis of dentin-containing tooth
GO:0043065	IMP:UniProtKB	P	positive regulation of apoptotic process
GO:0060139	IEA:Ensembl	P	positive regulation of apoptotic process by virus
GO:0045787	IEA:Ensembl	P	positive regulation of cell cycle
GO:0043280	IEA:Ensembl	P	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2000271	IDA:UniProtKB	P	positive regulation of fibroblast apoptotic process
GO:2001244	IMP:UniProtKB	P	positive regulation of intrinsic apoptotic signaling pathway
GO:1902110	IEA:Ensembl	P	positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:0043525	IEA:Ensembl	P	positive regulation of neuron apoptotic process
GO:0032464	IDA:BHF-UCL	P	positive regulation of protein homooligomerization
GO:1900740	TAS:Reactome	P	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0090200	IMP:UniProtKB	P	positive regulation of release of cytochrome c from mitochondria
GO:0048563	IEA:Ensembl	P	post-embryonic organ morphogenesis
GO:0048070	IEA:Ensembl	P	regulation of developmental pigmentation
GO:0046620	IEA:Ensembl	P	regulation of organ growth
GO:0034976	IDA:UniProtKB	P	response to endoplasmic reticulum stress
GO:0007283	IEA:Ensembl	P	spermatogenesis
GO:0048536	IEA:Ensembl	P	spleen development
GO:0043029	IEA:Ensembl	P	T cell homeostasis
GO:0070242	IEA:Ensembl	P	thymocyte apoptotic process
GO:0048538	IEA:Ensembl	P	thymus development
GO:0035148	IEA:Ensembl	P	tube formation

KEGG Pathway Links

KEGG Pathway ID	Description
hsa04068	FoxO signaling pathway
hsa05206	MicroRNAs in cancer
ko05206	MicroRNAs in cancer
hsa04932	Non-alcoholic fatty liver disease (NAFLD)
ko04932	Non-alcoholic fatty liver disease (NAFLD)
hsa04151	PI3K-Akt signaling pathway
ko04151	PI3K-Akt signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_697	Activation of BH3-only proteins
REACT_1650	Activation of BIM and translocation to mitochondria
REACT_578	Apoptosis
REACT_330	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
REACT_13720	Cell death signalling via NRAGE, NRIF and NADE
REACT_964	Intrinsic Pathway for Apoptosis
REACT_13638	NRAGE signals death through JNK
REACT_13776	p75 NTR receptor-mediated signalling
REACT_11061	Signalling by NGF
REACT_111102	Signal Transduction