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MT000790

UniProt Annotations

Entry Information

Gene Name	ADP-ribosylation factor-like 6 interacting protein 5
Protein Entry	PRAF3_HUMAN
UniProt ID	O75915
Species	Human

Comments

Comment type	Description
Function	Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic (By similarity). {ECO:0000250}.
Induction	By methyl-beta-cyclodextrin (By similarity). Up- regulated upon induced differentiation and in heat stress. {ECO:0000250, ECO:0000269\|PubMed:14761432}.
Sequence Caution	Sequence=BAD97286.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the PRA1 family. {ECO:0000305}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Also exists as a soluble form in the cytoplasm. Associated with microtubules (By similarity). {ECO:0000250}.
Subunit	Forms multimers. Binds to prenylated RAB1A and RAB3A, to the neuronal glutamate transporter SLC1A1/EAAC1, and to the ADP- ribosylation like factor ARL6, a member of the Ras superfamily. Does not bind to VAMP2 (By similarity). {ECO:0000250}.