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MT000849

Record overview

MITO IDMT000849
Gene ID11238
SpeciesHomo sapiens (Human)
Gene Namecarbonic anhydrase VB, mitochondrial
Gene SymbolCA5B
SynonymsCA-VB;
Alternate namescarbonic anhydrase 5B, mitochondrial; carbonic dehydratase; carbonate dehydratase VB;
ChromosomeX
Map LocationXp21.1
EC Number4.2.1.1
Summary Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CA5B

Proteins

carbonic anhydrase 5B, mitochondrial precursor
Refseq ID:NP_009151
Protein GI:6005723
UniProt ID:Q9Y2D0
mRNA ID:NM_007220
Length:317
RefSeq Status:
MVVMNSLRVILQASPGKLLWRKFQIPRFMPARPCSLYTCTYKTRNRALHPLWESVDLVPGGDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGY
SFLVEFEDSTDKSVIKGGPLEHNYRLKQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTL
PSIKHKDALVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDY
VLNVQAKPKPATSQATP
 
N
transit_peptide: 1..33
calculated_mol_wt: 3882
peptide sequence: 
MVVMNSLRVILQASPGKLLWRKFQIPRFMPARP

mat_peptide: 34..317
product: carbonic anhydrase 5B, mitochondrial
calculated_mol_wt: 32570
peptide sequence: 
CSLYTCTYKTRNRALHPLWESVDLVPGGDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPLEHNYRLKQFHFHW
GAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCLMPTCPDYWTYSGS
LTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDYVLNVQAKPKPATSQATP