MitoProteome Database

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MT000849

UniProt Annotations

Entry Information

Gene Name	carbonic anhydrase VB, mitochondrial
Protein Entry	CAH5B_HUMAN
UniProt ID	Q9Y2D0
Species	Human

Comments

Comment type	Description
Catalytic Activity	H(2)CO(3) = CO(2) + H(2)O.
Cofactor	Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
Enzyme Regulation	Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt). {ECO:0000269\|PubMed:17314045, ECO:0000269\|PubMed:17705204, ECO:0000269\|PubMed:19186056, ECO:0000269\|PubMed:19206230}.
Function	Reversible hydration of carbon dioxide.
Similarity	Belongs to the alpha-carbonic anhydrase family. {ECO:0000305}.
Subcellular Location	Mitochondrion.
Tissue Specificity	Strongest expression in heart, pancreas, kidney, placenta, lung, and skeletal muscle. Not expressed in liver.