MitoProteome Database

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MT000895

UniProt Annotations

Entry Information

Gene Name	dimethylarginine dimethylaminohydrolase 2
Protein Entry
UniProt ID
Species	Human

Comments

Comment type	Description
Catalytic Activity	N(omega),N(omega)-dimethyl-L-arginine + H(2)O = dimethylamine + L-citrulline. {ECO:0000269\|PubMed:10493931}.
Function	Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. {ECO:0000269\|PubMed:10493931}.
Interaction	Q15645:TRIP13; NbExp=3; IntAct=EBI-749139, EBI-358993;
Similarity	Belongs to the DDAH family. {ECO:0000305}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:21898353}. Mitochondrion {ECO:0000269\|PubMed:21898353}. Note=Translocates from cytosol to mitochondrion upon IL-1beta stimulation in chondrocytes.
Tissue Specificity	Detected in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas, and at very low levels in brain. {ECO:0000269\|PubMed:10493931}.