MitoProteome Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MT000928

Record overview

MITO IDMT000928
Gene ID25978
SpeciesHomo sapiens (Human)
Gene Namecharged multivesicular body protein 2B
Gene SymbolCHMP2B
SynonymsDMT1; ALS17; VPS2B; VPS2-2; CHMP2.5;
Alternate namescharged multivesicular body protein 2b; VPS2 homolog B; chromatin modifying protein 2B; vacuolar protein-sorting-associated protein 2-2;
Chromosome3
Map Location3p11.2
SummaryThis gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CHMP2B

Proteins

charged multivesicular body protein 2b isoform 1
Refseq ID:NP_054762
Protein GI:40254866
UniProt ID:Q9UQN3
mRNA ID:NM_014043
Length:213
RefSeq Status:
MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACKVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAG
AMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSASTSKATISD
EEIERQLKALGVD
 
charged multivesicular body protein 2b isoform 2
Refseq ID:NP_001231573
Protein GI:347582619
UniProt ID:Q9UQN3
mRNA ID:NM_001244644
Length:172
RefSeq Status:
MELEIKKMAKIGNKEACKVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEM
INDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSASTSKATISDEEIERQLKALGVD