MitoProteome Database

MT000959

Record overview

MITO ID	MT000959
Gene ID	27109
Species	Homo sapiens (Human)
Gene Name	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
Gene Symbol	ATP5S
Synonyms	FB; ATPW; HSU79253;
Alternate names	ATP synthase subunit s, mitochondrial; ATP synthase-coupling factor B; ATP synthase coupling factor B-like 1; ATP synthase coupling factor B, mitochondrial; mitochondrial ATP synthase regulatory component factor B; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B);
Chromosome	14
Map Location	14q21.3
Summary	This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for ATP5S

Proteins

ATP synthase subunit s, mitochondrial isoform a precursor

Refseq ID:	NP_001003803
Protein GI:	51558774
UniProt ID:	Q99766
mRNA ID:	NM_001003803
Length:	215
RefSeq Status:

`MCCAVSEQRLTCADQMMPFGKISQQLCGVKKLPWSCDSRYFWGWLNAVFNKVDYDRIRDVGPDRAASEWLLRCGAMVRYHGQERWQKDYNHLPTGPLDKY KIQAIDATDSCIMSIGFDHMEGLEHVEKIRLCKCHYIEDDCLLRLSQLENLQKTILEMEIISCGNITDKGIIALRHLRNLKYLLLSDLPGVREKENLVQA FKTALPSLELKLQLK`

N
transit_peptide: 1..40
calculated_mol_wt: 4543
peptide sequence: 
MCCAVSEQRLTCADQMMPFGKISQQLCGVKKLPWSCDSRY

mat_peptide: 41..215
product: ATP synthase subunit s, mitochondrial isoform a
calculated_mol_wt: 20341
peptide sequence: 
FWGWLNAVFNKVDYDRIRDVGPDRAASEWLLRCGAMVRYHGQERWQKDYNHLPTGPLDKYKIQAIDATDSCIMSIGFDHMEGLEHVEKIRLCKCHYIEDD
CLLRLSQLENLQKTILEMEIISCGNITDKGIIALRHLRNLKYLLLSDLPGVREKENLVQAFKTALPSLELKLQLK

ATP synthase subunit s, mitochondrial isoform b precursor

Refseq ID:	NP_001003805
Protein GI:	51558777
UniProt ID:	Q99766
mRNA ID:	NM_001003805
Length:	127
RefSeq Status:

`MCCAVSEQRLTCADQMMPFGKISQQLCGVKKLPWSCDSRYFWGWLNAVFNKVDYDRIRDVGPDRAASEWLLRCGAMVRYHGQERWQKDYNHLPTGPLDKY KIQAIDATDSCIMSIGFDHMETSNICC`

N
transit_peptide: 1..40
calculated_mol_wt: 4543
peptide sequence: 
MCCAVSEQRLTCADQMMPFGKISQQLCGVKKLPWSCDSRY

mat_peptide: 41..215
product: ATP synthase subunit s, mitochondrial isoform a
calculated_mol_wt: 20341
peptide sequence: 
FWGWLNAVFNKVDYDRIRDVGPDRAASEWLLRCGAMVRYHGQERWQKDYNHLPTGPLDKYKIQAIDATDSCIMSIGFDHMEGLEHVEKIRLCKCHYIEDD
CLLRLSQLENLQKTILEMEIISCGNITDKGIIALRHLRNLKYLLLSDLPGVREKENLVQAFKTALPSLELKLQLK

transit_peptide: 1..40
calculated_mol_wt: 4543
peptide sequence: 
MCCAVSEQRLTCADQMMPFGKISQQLCGVKKLPWSCDSRY

mat_peptide: 41..136
product: ATP synthase subunit s, mitochondrial isoform c
calculated_mol_wt: 11160
peptide sequence: 
FWGWLNAVFNKVDYDRIRDVGPDRAASEWLLRCGAMVRYHGQERWQKDYNHLPTGPLDKYKIQAIDATDSCIMSIGFDHMGNYPIVLLIENADDLQ

transit_peptide: 1..40
calculated_mol_wt: 4543
peptide sequence: 
MCCAVSEQRLTCADQMMPFGKISQQLCGVKKLPWSCDSRY

mat_peptide: 41..127
product: ATP synthase subunit s, mitochondrial isoform b
calculated_mol_wt: 10142
peptide sequence: 
FWGWLNAVFNKVDYDRIRDVGPDRAASEWLLRCGAMVRYHGQERWQKDYNHLPTGPLDKYKIQAIDATDSCIMSIGFDHMETSNICC

ATP synthase subunit s, mitochondrial isoform c precursor

Refseq ID:	NP_056499
Protein GI:	51558768
UniProt ID:	Q99766
mRNA ID:	NM_015684
Length:	136
RefSeq Status:

`MCCAVSEQRLTCADQMMPFGKISQQLCGVKKLPWSCDSRYFWGWLNAVFNKVDYDRIRDVGPDRAASEWLLRCGAMVRYHGQERWQKDYNHLPTGPLDKY KIQAIDATDSCIMSIGFDHMGNYPIVLLIENADDLQ`

N
transit_peptide: 1..40
calculated_mol_wt: 4543
peptide sequence: 
MCCAVSEQRLTCADQMMPFGKISQQLCGVKKLPWSCDSRY

mat_peptide: 41..215
product: ATP synthase subunit s, mitochondrial isoform a
calculated_mol_wt: 20341
peptide sequence: 
FWGWLNAVFNKVDYDRIRDVGPDRAASEWLLRCGAMVRYHGQERWQKDYNHLPTGPLDKYKIQAIDATDSCIMSIGFDHMEGLEHVEKIRLCKCHYIEDD
CLLRLSQLENLQKTILEMEIISCGNITDKGIIALRHLRNLKYLLLSDLPGVREKENLVQAFKTALPSLELKLQLK

transit_peptide: 1..40
calculated_mol_wt: 4543
peptide sequence: 
MCCAVSEQRLTCADQMMPFGKISQQLCGVKKLPWSCDSRY

mat_peptide: 41..136
product: ATP synthase subunit s, mitochondrial isoform c
calculated_mol_wt: 11160
peptide sequence: 
FWGWLNAVFNKVDYDRIRDVGPDRAASEWLLRCGAMVRYHGQERWQKDYNHLPTGPLDKYKIQAIDATDSCIMSIGFDHMGNYPIVLLIENADDLQ