MitoProteome Database

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MT000959

UniProt Annotations

Entry Information

Gene Name	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
Protein Entry	ATP5S_HUMAN
UniProt ID	Q99766
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q99766-1; Sequence=Displayed; Name=2; IsoId=Q99766-2; Sequence=VSP_040059, VSP_040062; Name=3; IsoId=Q99766-3; Sequence=VSP_040060, VSP_040061;
Caution	It is uncertain whether Met-1 or Met-16 is the initiator. {ECO:0000305}.
Function	Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway (By similarity). {ECO:0000250}.
Similarity	Belongs to the ATP synthase subunit s family. {ECO:0000305}.
Similarity	Contains 4 LRR (leucine-rich) repeats. {ECO:0000305}.
Subcellular Location	Mitochondrion {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}.
Subunit	Homotetramer. Associates with ATP synthase (By similarity). {ECO:0000250}.