MitoProteome Database

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MT000976

UniProt Annotations

Entry Information

Gene Name	cytochrome c oxidase assembly factor 3
Protein Entry	COA3_HUMAN
UniProt ID	Q9Y2R0
Species	Human

Comments

Comment type	Description
Function	Component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex that regulates COX assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly. {ECO:0000269\|PubMed:23260140}.
Interaction	P00395:MT-CO1; NbExp=11; IntAct=EBI-6570446, EBI-2117234; Q15526:SURF1; NbExp=6; IntAct=EBI-6570446, EBI-3915286;
Similarity	Belongs to the COA3 family. {ECO:0000305}.
Subcellular Location	Mitochondrion inner membrane {ECO:0000269\|PubMed:23260140}; Single-pass membrane protein {ECO:0000269\|PubMed:23260140}.
Subunit	Component of some MITRAC complex. {ECO:0000269\|PubMed:23260140}.