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MT001069

Record overview

MITO IDMT001069
Gene ID51700
SpeciesHomo sapiens (Human)
Gene Namecytochrome b5 reductase 2
Gene SymbolCYB5R2
SynonymsB5R.2;
Alternate namesNADH-cytochrome b5 reductase 2; cytochrome b5 reductase b5R.2;
Chromosome11
Map Location11p15.4
EC Number1.6.2.2;
SummaryThe protein encoded by this gene belongs to the flavoprotein pyridine nucleotide cytochrome reductase family of proteins. Cytochrome b-type NAD(P)H oxidoreductases are implicated in many processes including cholesterol biosynthesis, fatty acid desaturation and elongation, and respiratory burst in neutrophils and macrophages. Cytochrome b5 reductases have soluble and membrane-bound forms that are the product of alternative splicing. In animal cells, the membrane-bound form binds to the endoplasmic reticulum, where it is a member of a fatty acid desaturation complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
OrthologsView orthologs and multiple alignments for CYB5R2

Proteins

NADH-cytochrome b5 reductase 2 isoform 1
Refseq ID:NP_057313
Protein GI:47778923
UniProt ID:Q6BCY4
mRNA ID:NM_016229
Length:276
RefSeq Status:
MNSRRREPITLQDPEAKYPLPLIEKEKISHNTRRFRFGLPSPDHVLGLPVGNYVQLLAKIDNELVVRAYTPVSSDDDRGFVDLIIKIYFKNVHPQYPEGG
KMTQYLENMKIGETIFFRGPRGRLFYHGPGNLGIRPDQTSEPKKTLADHLGMIAGGTGITPMLQLIRHITKDPSDRTRMSLIFANQTEEDILVRKELEEI
ARTHPDQFNLWYTLDRPPIGWKYSSGFVTADMIKEHLPPPAKSTLILVCGPPPLIQTAAHPNLEKLGYTQDMIFTY
 
NADH-cytochrome b5 reductase 2 isoform 1
Refseq ID:NP_001289755
Protein GI:723586615
UniProt ID:
mRNA ID:NM_001302826
Length:276
RefSeq Status:
Protein sequence is identical to GI:47778923 (mRNA isoform)
 
NADH-cytochrome b5 reductase 2 isoform 2
Refseq ID:NP_001289756
Protein GI:723586612
UniProt ID:
mRNA ID:NM_001302827
Length:230
RefSeq Status:
MNSRRREPITLQDPEAKYPLPLIEKEKISHNTRRFRFGLPSPDHVLGLPVGNYVQLLAKIDNELVVRAYTPVSSDDDRGFVDLIIKIYFKNVHPQYPEGG
KMTQYLENMKIGETIFFRGPRGRLFYHGPGNLGIRPDQTSEPKKTLADHLGMIAGGTGITPMLQLIRHITKDPSDRTRMSLIFANQRRISWSEKSLKKLP
GLTQTSSTCGTPWTGLPLAGSTAQASLLPT