MitoProteome Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins

MT001069

UniProt Annotations

Entry Information

Gene Name	cytochrome b5 reductase 2
Protein Entry
UniProt ID
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6BCY4-1; Sequence=Displayed; Name=2; IsoId=Q6BCY4-2; Sequence=VSP_025559; Note=No experimental confirmation available.;
Catalytic Activity	NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5.
Cofactor	Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
Function	NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4- disulfophenyl]-2H tetrazolium monosodium salt (WST-1). {ECO:0000250, ECO:0000269\|PubMed:15858218}.
Similarity	Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. {ECO:0000305}.
Similarity	Contains 1 FAD-binding FR-type domain. {ECO:0000255\|PROSITE-ProRule:PRU00716}.
Tissue Specificity	Restricted expression. {ECO:0000269\|PubMed:10611283}.