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MT001100

Record overview

MITO IDMT001100
Gene ID54920
SpeciesHomo sapiens (Human)
Gene Namedihydrouridine synthase 2
Gene SymbolDUS2
SynonymsSMM1; DUS2L; URLC8;
Alternate namestRNA-dihydrouridine(20) synthase [NAD(P)+]-like; SMM1 homolog; up-regulated in lung cancer protein 8; dihydrouridine synthase 2-like, SMM1 homolog;
Chromosome16
Map Location16q22.1
EC Number1.3.1.-
SummaryThis gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
OrthologsView orthologs and multiple alignments for DUS2

Proteins

tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 1
Refseq ID:NP_001258691
Protein GI:419635745
UniProt ID:Q9NX74
mRNA ID:NM_001271762
Length:493
RefSeq Status:
MILNSLSLCYHNKLILAPMVRVGTLPMRLLALDYGADIVYCEELIDLKMIQCKRVVNEVLSTVDFVAPDDRVVFRTCEREQNRVVFQMGTSDAERALAVA
RLVENDVAGIDVNMGCPKQYSTKGGMGAALLSDPDKIEKILSTLVKGTRRPVTCKIRILPSLEDTLSLVKRIERTGIAAIAVHGRKREERPQHPVSCEVI
KAIADTLSIPVIANGGSHDHIQQYSDIEDFRQATAASSVMVARAAMWNPSIFLKEGLRPLEEVMQKYIRYAVQYDNHYTNTKYCLCQMLREQLESPQGRL
LHAAQSSREICEAFGLGAFYEETTQELDAQQARLSAKTSEQTGEPAEDTSGVIKMAVKFDRRAYPAQITPKMCLLEWCRREKLAQPVYETVQRPLDRLFS
SIVTVAEQKYQSTLWDKSKKLAEQAAAIVCLRSQGLPEGRLGEESPSLHKRKREAPDQDPGGPRAQELAQPGDLCKKPFVALGSGEESPLEGW
 
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 1
Refseq ID:NP_060273
Protein GI:8923374
UniProt ID:Q9NX74
mRNA ID:NM_017803
Length:493
RefSeq Status:
Protein sequence is identical to GI:419635745 (mRNA isoform)
 
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 2
Refseq ID:NP_001258692
Protein GI:419635906
UniProt ID:Q9NX74
mRNA ID:NM_001271763
Length:458
RefSeq Status:
MILNSLSLCYHNKLILAPMVRVGTLPMRLLALDYGADIVYCEELIDLKMIQCKRVVNEVLSTVDFVAPDDRVVFRTCEREQNRVVFQMGGMGAALLSDPD
KIEKILSTLVKGTRRPVTCKIRILPSLEDTLSLVKRIERTGIAAIAVHGRKREERPQHPVSCEVIKAIADTLSIPVIANGGSHDHIQQYSDIEDFRQATA
ASSVMVARAAMWNPSIFLKEGLRPLEEVMQKYIRYAVQYDNHYTNTKYCLCQMLREQLESPQGRLLHAAQSSREICEAFGLGAFYEETTQELDAQQARLS
AKTSEQTGEPAEDTSGVIKMAVKFDRRAYPAQITPKMCLLEWCRREKLAQPVYETVQRPLDRLFSSIVTVAEQKYQSTLWDKSKKLAEQAAAIVCLRSQG
LPEGRLGEESPSLHKRKREAPDQDPGGPRAQELAQPGDLCKKPFVALGSGEESPLEGW