MitoProteome Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins

MT001100

UniProt Annotations

Entry Information

Gene Name	dihydrouridine synthase 2
Protein Entry	DUS2L_HUMAN
UniProt ID	Q9NX74
Species	Human

Comments

Comment type	Description
Cofactor	Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
Function	Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. {ECO:0000269\|PubMed:15994936, ECO:0000269\|PubMed:18096616}.
Similarity	Belongs to the Dus family. Dus2 subfamily. {ECO:0000305}.
Similarity	Contains 1 DRBM (double-stranded RNA-binding) domain. {ECO:0000305}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:15994936}. Endoplasmic reticulum {ECO:0000269\|PubMed:15994936}. Note=Mainly at the endoplasmic reticulum.
Subunit	Interacts with EPRS. Interacts (via DRBM domain) with PRKRA and EIF2AK2/PKR (via DRBM 1 domain). {ECO:0000269\|PubMed:15994936, ECO:0000269\|PubMed:18096616}.
Tissue Specificity	Weak expression in heart, placenta and skeletal muscle. Up-regulated in most lung cancer cells (at protein level). {ECO:0000269\|PubMed:15994936}.