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MT001191

UniProt Annotations

Entry Information

Gene Name	CTP synthase 2
Protein Entry	PYRG2_HUMAN
UniProt ID	Q9NRF8
Species	Human

Comments

Comment type	Description
Catalytic Activity	ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.
Function	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. {ECO:0000269\|PubMed:10899599, ECO:0000269\|PubMed:16179339}.
Pathway	Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.
Similarity	Belongs to the CTP synthase family. {ECO:0000305}.
Similarity	Contains 1 glutamine amidotransferase type-1 domain. {ECO:0000255\|PROSITE-ProRule:PRU00605}.