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MT001220

UniProt Annotations

Entry Information

Gene Name	arsenite methyltransferase
Protein Entry	AS3MT_HUMAN
UniProt ID	Q9HBK9
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Comment=An isoform missing exon 3 is produced with a premature stop codon at AA 23 and is targeted to nonsense-mediated mRNA decay (NMD).; Name=1; IsoId=Q9HBK9-1; Sequence=Displayed; Name=2; Synonyms=31.1 kDa, delta4,5; IsoId=Q9HBK9-2; Sequence=VSP_053494; Note=Devoid of methyltransferase activity.;
Biophysicochemical Properties	Kinetic parameters: KM=4.6 uM for sodium arsenite {ECO:0000269\|PubMed:16407288}; KM=11.8 uM for AdoMet {ECO:0000269\|PubMed:16407288};
Catalytic Activity	S-adenosyl-L-methionine + arsenite = S- adenosyl-L-homocysteine + methylarsonate.
Catalytic Activity	S-adenosyl-L-methionine + methylarsonite = S- adenosyl-L-homocysteine + dimethylarsinate.
Function	Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity). {ECO:0000250}.
Sequence Caution	Sequence=AAG09731.1; Type=Frameshift; Positions=333; Evidence={ECO:0000305};
Similarity	Belongs to the methyltransferase superfamily. {ECO:0000305}.
Subcellular Location	Cytoplasm {ECO:0000250}.