MitoProteome Database

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MT001307

UniProt Annotations

Entry Information

Gene Name	apolipoprotein O
Protein Entry	APOO_HUMAN
UniProt ID	Q9BUR5
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BUR5-1; Sequence=Displayed; Name=2; IsoId=Q9BUR5-2; Sequence=VSP_023333;
Function	Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation. {ECO:0000269\|PubMed:16956892}.
Ptm	O-glycosylation; glycosaminoglycan of chondroitin-sulfate type.
Similarity	Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family. {ECO:0000305}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Secreted {ECO:0000269\|PubMed:16956892}.
Tissue Specificity	Expressed in all tissues examined. Up- regulated in diabetic heart. {ECO:0000269\|PubMed:16956892}.