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MT001382

UniProt Annotations

Entry Information

Gene Name	armadillo repeat containing 10
Protein Entry	ARM10_HUMAN
UniProt ID	Q8N2F6
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=SVH-A; IsoId=Q8N2F6-1; Sequence=Displayed; Name=2; Synonyms=SVH-B; IsoId=Q8N2F6-2; Sequence=VSP_027361; Note=Contains a phosphoserine at position 45. Contains a phosphothreonine at position 50.; Name=3; Synonyms=SVH-C; IsoId=Q8N2F6-3; Sequence=VSP_027362; Name=4; Synonyms=SVH-D; IsoId=Q8N2F6-4; Sequence=VSP_027361, VSP_027362; Note=Contains a phosphoserine at position 45. Contains a phosphothreonine at position 50.; Name=5; IsoId=Q8N2F6-5; Sequence=VSP_027361, VSP_043290; Note=No experimental confirmation available. Contains a phosphoserine at position 45. Contains a phosphothreonine at position 50.; Name=6; IsoId=Q8N2F6-6; Sequence=VSP_027361, VSP_047404; Note=Gene prediction based on EST data. Contains a phosphoserine at position 45. Contains a phosphothreonine at position 50.;
Function	May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53. {ECO:0000269\|PubMed:12839973, ECO:0000269\|PubMed:17904127}.
Miscellaneous	Depletion of isoform 2 results in cell apoptosis while its overexpression in cells leads to accelerated growth rate and tumorogenicity.
Sequence Caution	Sequence=AAS07482.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity	Contains 1 ARM repeat. {ECO:0000305}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269\|PubMed:12839973}; Single-pass membrane protein {ECO:0000269\|PubMed:12839973}.
Subunit	Interacts with the DNA-binding domain of p53/TP53. {ECO:0000269\|PubMed:17904127}.
Tissue Specificity	Expressed in all tissues tested with higher expression in placenta, liver, kidney, heart and brain. {ECO:0000269\|PubMed:12839973}.