MitoProteome Database

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MT001408

UniProt Annotations

Entry Information

Gene Name	apoptogenic 1, mitochondrial
Protein Entry
UniProt ID
Species	Human

Comments

Comment type	Description
Caution	It is uncertain whether Met-1 or Met-14 is the initiator. {ECO:0000305}.
Function	Plays a role in the regulation of apoptosis. Mediates mitochondria-induced cell death in vascular smooth muscle cells through the release of cytochrome c from mitochondria, followed by the activation of the caspase cascade. {ECO:0000250\|UniProtKB:Q9CQW7}.
Sequence Caution	Sequence=AAH07412.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD96812.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD96823.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity	Belongs to the APOPT family. {ECO:0000305}.
Subcellular Location	Mitochondrion {ECO:0000250\|UniProtKB:Q9CQW7}.