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MT001416

Record overview

MITO IDMT001416
Gene ID84649
SpeciesHomo sapiens (Human)
Gene Namediacylglycerol O-acyltransferase 2
Gene SymbolDGAT2
SynonymsARAT; HMFN1045; GS1999FULL;
Alternate namesdiacylglycerol O-acyltransferase 2; diglyceride acyltransferase 2; retinol O-fatty-acyltransferase; acyl-CoA retinol O-fatty-acyltransferase; diacylglycerol O-acyltransferase homolog 2; diacylglycerol O-acyltransferase-like protein 2;
Chromosome11
Map Location11q13.5
EC Number2.3.1.20
SummaryThis gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
OrthologsView orthologs and multiple alignments for DGAT2

Proteins

diacylglycerol O-acyltransferase 2 isoform 1
Refseq ID:NP_115953
Protein GI:26024197
UniProt ID:Q96PD7
mRNA ID:NM_032564
Length:388
RefSeq Status:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCW
LIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFR
MPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
 
diacylglycerol O-acyltransferase 2 isoform 2
Refseq ID:NP_001240820
Protein GI:359806523
UniProt ID:Q96PD7
mRNA ID:NM_001253891
Length:345
RefSeq Status:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQ
LVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAE
SLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPIT
IPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN