MitoProteome Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins

MT001416

UniProt Annotations

Entry Information

Gene Name	diacylglycerol O-acyltransferase 2
Protein Entry	DGAT2_HUMAN
UniProt ID	Q96PD7
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96PD7-1; Sequence=Displayed; Name=2; IsoId=Q96PD7-2; Sequence=VSP_020356;
Catalytic Activity	Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. {ECO:0000269\|PubMed:16214399}.
Catalytic Activity	Acyl-CoA + retinol = CoA + retinyl ester. {ECO:0000269\|PubMed:16214399}.
Enzyme Regulation	Inhibited by niacin. {ECO:0000250}.
Function	Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT). {ECO:0000250}.
Pathway	Glycerolipid metabolism; triacylglycerol biosynthesis.
Sequence Caution	Sequence=BAD38635.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD38961.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the diacylglycerol acyltransferase family. {ECO:0000305}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269\|PubMed:14521909}; Multi-pass membrane protein {ECO:0000269\|PubMed:14521909}. Lipid droplet {ECO:0000250}.
Subunit	Forms multimeric complexes consisting of several DGAT2 subunits. {ECO:0000250}.
Tissue Specificity	Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin. {ECO:0000269\|PubMed:11481335, ECO:0000269\|PubMed:14521909}.