MitoProteome Database

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MT001587

Gene Information

Entrez Gene ID200895
Gene Namedihydrofolate reductase-like 1
Gene SymbolDHFRL1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005743 IMP:UniProtKBCmitochondrial inner membrane
GO:0005759 IMP:UniProtKBCmitochondrial matrix
GO:0005739 IDA:UniProtKBCmitochondrion
GO:0004146 IMP:UniProtKBFdihydrofolate reductase activity
GO:0003729 IDA:UniProtKBFmRNA binding
GO:0050661 IEA:InterProFNADP binding
GO:0006545 IEA:InterProPglycine biosynthetic process
GO:0009165 IEA:InterProPnucleotide biosynthetic process
GO:0006730 IEA:UniProtKB-KWPone-carbon metabolic process
GO:0046654 IEA:UniProtKB-UniPathwayPtetrahydrofolate biosynthetic process
GO:0046653 IDA:UniProtKBPtetrahydrofolate metabolic process
GO:0046105 IDA:UniProtKBPthymidine biosynthetic process
KEGG Pathway Links
KEGG Pathway IDDescription
hsa00790Folate biosynthesis
ko00790Folate biosynthesis
hsa01100Metabolic pathways
hsa00670One carbon pool by folate
ko00670One carbon pool by folate
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_169280Defective AMN causes hereditary megaloblastic anemia 1
REACT_169403Defective BTD causes biotidinase deficiency
REACT_169178Defective CD320 causes methylmalonic aciduria
REACT_169132Defective CUBN causes hereditary megaloblastic anemia 1
REACT_169415Defective GIF causes intrinsic factor deficiency
REACT_169312Defective HLCS causes multiple carboxylase deficiency
REACT_169363Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
REACT_169316Defective MMAA causes methylmalonic aciduria type cblA
REACT_169318Defective MMAB causes methylmalonic aciduria type cblB
REACT_169169Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
REACT_169256Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
REACT_169149Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
REACT_169439Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
REACT_169313Defective MUT causes methylmalonic aciduria mut type
REACT_169120Defective TCN2 causes hereditary megaloblastic anemia
REACT_169238Defects in biotin (Btn) metabolism
REACT_169429Defects in cobalamin (B12) metabolism
REACT_169385Defects in vitamin and cofactor metabolism
REACT_116125Disease
REACT_111217Metabolism
REACT_11167Metabolism of folate and pterines
REACT_11193Metabolism of vitamins and cofactors
REACT_11238Metabolism of water-soluble vitamins and cofactors