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MT001587

UniProt Annotations

Entry Information

Gene Name	dihydrofolate reductase-like 1
Protein Entry	DYRL1_HUMAN
UniProt ID	Q86XF0
Species	Human

Comments

Comment type	Description
Biophysicochemical Properties	Kinetic parameters: KM=209 uM for dihydrofolate {ECO:0000269\|PubMed:21876184}; KM=20 uM for NADPH {ECO:0000269\|PubMed:21876184};
Catalytic Activity	5,6,7,8-tetrahydrofolate + NADP(+) = 7,8- dihydrofolate + NADPH. {ECO:0000255\|PROSITE-ProRule:PRU00660, ECO:0000269\|PubMed:21876184}.
Function	Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR. {ECO:0000269\|PubMed:21876184, ECO:0000269\|PubMed:21876188}.
Pathway	Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
Similarity	Belongs to the dihydrofolate reductase family. {ECO:0000305}.
Similarity	Contains 1 DHFR (dihydrofolate reductase) domain. {ECO:0000255\|PROSITE-ProRule:PRU00660}.
Subcellular Location	Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane.
Tissue Specificity	Expressed in numerous cell lines. {ECO:0000269\|PubMed:21876184}.