MitoProteome Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MT001599

UniProt Annotations

Entry Information
Gene NamealkB, alkylation repair homolog 3 (E. coli)
Protein EntryALKB3_HUMAN
UniProt IDQ96Q83
SpeciesHuman
Comments
Comment typeDescription
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96Q83-1; Sequence=Displayed; Name=2; IsoId=Q96Q83-2; Sequence=VSP_019125, VSP_019126, VSP_019127; Note=No experimental confirmation available.;
Cofactor Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) ion per subunit.;
Enzyme Regulation Activated by ascorbate. {ECO:0000269|PubMed:12486230}.
Function Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron. {ECO:0000269|PubMed:12486230, ECO:0000269|PubMed:12594517, ECO:0000269|PubMed:16174769, ECO:0000269|PubMed:22055184}.
Sequence Caution Sequence=AAH15155.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the alkB family. {ECO:0000305}.
Similarity Contains 1 Fe2OG dioxygenase domain. {ECO:0000255|PROSITE-ProRule:PRU00805}.
Subcellular Location Cytoplasm. Nucleus.
Subunit Interacts with the TRIP4 complex, notably composed of ASCC3. {ECO:0000269|PubMed:16858410, ECO:0000269|PubMed:22055184}.
Tissue Specificity Ubiquitous. Detected in heart, pancreas, skeletal muscle, thymus, testis, ovary, spleen, prostate, small intestine, peripheral blood leukocytes, urinary bladder and colon. {ECO:0000269|PubMed:12486230, ECO:0000269|PubMed:16174769, ECO:0000269|PubMed:17979886}.
Web Resource Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/depc1/";